Objective: To evaluate the long-term tolerability and effectiveness of extended-release mixed amphetamine salts (MAS XR Adderall XR) in children with attention-deficit/hyperactivity disorder (ADHD). Spencer, Thomas Zhang, Yuxin Tulloch, Simon J. Long-Term Tolerability and Effectiveness of Once-Daily Mixed Amphetamine Salts (Adderall XR) in Children with ADHD In the study, OROS methylphenidate promoted significantly improved driving performance compared with placebo and mixed amphetamine salts extended release. This study validates the use of stimulants to improve driving performance in adolescents with attention-deficit/hyperactivity disorder. OROS methylphenidate and mixed amphetamine salts extended release worked equally well for male and female adolescents and equally as well with teenagers who have combined and inattentive subtypes of attention-deficit/hyperactivity disorder. Specifically, relative to placebo, OROS methylphenidate resulted in less time driving off the road, fewer instances of speeding, less erratic speed control, more time executing left turns, and less inappropriate use of brakes. The overall Impaired Driving Score demonstrated that OROS methylphenidate led to better driving performance compared with placebo and mixed amphetamine salts extended release, whereas mixed amphetamine salts extended release demonstrated no statistical improvement over placebo. The study included 35 adolescent drivers with attention-deficit/hyperactivity disorder (19 boys/16 girls). Driving performance was rated by adolescents and investigators. During laboratory testing, adolescents drove a driving simulator at 5:00 pm, 8:00 pm, and 11:00 pm. Adolescent drivers with attention-deficit/hyperactivity disorder were compared on a driving simulator after taking 72 mg of OROS methylphenidate, 30 mg of mixed amphetamine salts extended release, or placebo in a randomized, double-blind, placebo-controlled, crossover study design. This study compared 2 long-acting stimulant medications during daytime and evening driving evaluations. Studies have demonstrated that stimulants improve driving performance. Relative benefits of stimulant therapy with OROS methylphenidate versus mixed amphetamine salts extended release in improving the driving performance of adolescent drivers with attention-deficit/hyperactivity disorder.Ĭox, Daniel J Merkel, R Lawrence Moore, Melissa Thorndike, Frances Muller, Carrie Kovatchev, BorisĪutomobile accidents are the leading cause of death among adolescents, and collisions are 2 to 4 times more likely to occur among adolescents with attention-deficit/hyperactivity disorder. Method: This was a randomized, double-blind, placebo-controlled, crossover study of simulated driving performance with mixed amphetamine salts-extended release (MAS XR) 50 mg/day (Cohort 1) and… Alex Pakull, Bartonīackground: Psychostimulant treatment may improve simulated driving performance in young adults with attention-deficit/hyperactivity disorder (ADHD). Simulated Driving Changes in Young Adults with ADHD Receiving Mixed Amphetamine Salts Extended Release and AtomoxetineĮRIC Educational Resources Information Center Potential neurobiologic mechanisms for dissociative symptom improvement with psychostimulants are discussed. Here the case of a woman with severe dissociative symptoms that were markedly improved with the administration of mixed amphetamine salts is discussed. There is currently no established psychopharmacologic treatment for dissociative symptoms. Dissociation likely involves dysregulated balance of prefrontal inhibition of limbic structures and inadequate regulation of attentional bias by both prefrontal and limbic systems. This includes the trauma of environmental inability to facilitate development of adequate cognitive strategies for coping with strong negative emotions. Symptoms of dissociation, including dissociative amnesia, depersonalization, and derealization, commonly develop in individuals subject to chronic and repeated trauma during development. Case report: Improvement in dissociative symptoms with mixed amphetamine salts.
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